Monday, November 20, 2006


By David Berman, MD

So you say your 15 year old doesn’t pay attention in school, he fidgets in class, is sometimes disruptive and is just barely getting by grade wise. But wait. Recently he’s been doing a lot better. He’s keeping up with his homework and his grades have gone from C minuses to As and Bs. Then all of a sudden he’s back to his old tricks, busted at school for marijuana.

Maybe we need to take a closer look and see if there really is something more significant going on. Maybe, just maybe, the scientists who are studying the endocannabinoid system and clinicians treating patients with cannabis, cannabinoids and anandamide blockers are right and he really is treating his ADHD. Your first reaction is to dismiss that idea. But read on and you won’t be so quick to be influenced by 90 years of unscientific propaganda.

ADHD is a costly problem that strains medical/mental health, educational, and legal institutions. ADHD afflicts 3-5% of Americans. It is one of the most common psychiatric disorders of childhood and in adults frequently results in tragic consequences in professional and personal lives. ADHD is characterized by persistent impairments in attention (or concentration) and/or symptoms of hyperactivity and impulsivity.

The preponderance of studies show marijuana use is overwhelmingly prevalent with ADHD sufferers, either as a self-medicament or for recreation. While some apply preconceptions that marijuana exacerbates ADHD almost all California cannabinologists believe camnabis and cannabinoids have substantially improved the lives of ADHD sufferers, and with less negative side effects than common stimulant drug ADHD treatments.

As we have come to understand more about the brain and the role of dopamine and the endocannabinoid system we are starting to unravel how cannabis, anandamide and dranabinol act to free up dopamine and decrease the overstimulation of the midbrain. But before we jump to the present we need to recognize that ADHD sufferers react differently to stimulant drugs from the average population[4]. This was first noted in 1937 when Dr. Charles Bradley attempted to treat the first recognized cases of ADHD.(ADHD has gone by the names of Minimal Brain Dysfunction [MBD], hyperkinesis, etc.) After trying sedatives his patients became more hyperactive. Noting this paradox he tried amphetamine, which calmed them down.

From that point, stimulants (sympathomimetic drugs) became the mainstay for treating ADHD. It turns out that they work by tying up dopamine transporter thus freeing up dopamine, previously bound to the dopamine transporter, to engage in retrograde inhibition. Dopamine is essentially acting as a damper on neurotransmission by depolarizing the neuron that just released it. The stimulants main draw back is that they come with a host of unacceptable side effects-jitteriness, anxiety, sleep difficulty, appetite suppression and a propensity to be quick to anger.

It turns out that cannabis also frees up dopamine but it has a very benign side effect profile. Noting cannabis’ vastly superior side effect profile DEA Administrative Law Judge, Francis L. Young, after a two-year hearing to reschedule cannabis in 1998 said:

"Nearly all medicines have toxic, potentially lethal effects. But marijuana is not such a substance. There is no record in the extensive medical literature describing a proven, documented cannabis-induced fatality .... In strict medical terms marijuana is far safer than many foods we commonly consume ... Marijuana, in its natural form, is one of the safest therapeutically active substances known to man."

The results in treating ADHD with cannabis are often spectacular .Patients report grades going from Cs and Ds to As and Bs. Dr. David Bearman, a physician practicing in Santa Barbara California, reports patients have said “I graduated from the Maritime Academy

because I smoked marijuana”, and “I got my Ph. D because of smoking marijuana.” Almost universally ADHD patients who therapeutically used cannabis reported it helped them pay attention in lecture, focus their attention instead of thinking of several ideas almost at the same time, helped them to stay on task and do their homework.

Marijuana Science & the Brain

In the 1940s tetrahydrocannabinol (THC) was identified as the major psychoactive in marijuana.In 1964 Israeli scientist Rapheal Mechulam, isolated the most pharmacologically active of the 483 chemical in cannabis,delta 9 THC. While the psychoactive effects of marijuana are still mostly attributed to THC[1] several cannabinoids, flavinoids and terpenoids also from cannabis, are thought to have therapeutic value.

In the 1990s, scientists discovered vast amounts of THC receptors in the mammalian (e.g., cows, dolphins, humans) central nervous system. This system is now known as the endocannabinoid system and is a major part of the human brain. Its importance was accepted when it was learned that THC receptors exist in greater numbers than receptors for hundreds of drugs used in modern medicine. This initiated widespread medical interest in marijuana; new findings appear almost daily in the medical literature.

The first cannabinoid-receptors in the human brain were named CB1 and CB2. They are located in high concentration in the midbrain in the limbic system and in the forebrain of the cerebral cortex. Soon it was found that the human brain produces over 60 endocannabinoids (i.e., THC-like substances). Endocannabinoids exert most of their pharmacological actions by activating the CB1 receptor in the brain. While the brain produces its own cannabinoids, smoking marijuana also stimulates the body's endocannabinoid system.

70% of the brain's job is to inhibit sensory input from the other 30%
Typical ADHD symptoms include distractibility. The most accepted theory about ADHD rests on the fact that about 70% of the brain’s function is to regulate input to the other 30%. The cause of ADHD is probably a decreased ability to suppress sensory input both internal and external input. Basically the brain is overwhelmed with to much information come to fast. In ADHD the brain is cluttered with and too aware of all the nuances of a person’s daily experience. This phenomenon is caused by a dopamine dysfunction.

Dopamine (a neurotransmitter in the brain) is a key suppressor of stimuli to the brain.It works by a unique mechanism, retrograde inhibition. By the dopamine depolarizing the neuron that just released it, that neuron becomes more difficult to stimulate and the speed and frequency of neural firing in that part of the brain is decreased. Without dopamine, we cannot distinguish or maybe we should say, focus and concentrate on what is important information (a boss giving us important instructions) from not so important information (e.g., daydreams). Persons with ADHD have significant irregularities in their dopamine management systems[1]

In the late 1990’s, researchers discovered how Ritalin®, the popular ADHD treatment, works¾it increases dopamine levels[2]. The story would have ended there if Ritalin did not have significant potential to cause permanent brain damage and psychiatric problems[3],[4]. (Bill this seems way too strong) Even non-stimulant ADHD drugs have serious psychiatric problems[5].

Since the endocannabinoid system was discovered, many studies revealed that marijuana also modulates the dopamine system[6] and therefore is a potential ADHD treatment. As recounted in the physicians’ stories below, marijuana may a safer, less costly, and more effective treatment than anything available from the pharmaceutical companies.

Doctors Speak Up

Dr. Claudia Jensen, a 49-year old California pediatrician and mother of 2 teenage daughters, says marijuana might be the best treatment for ADHD. In a recent interview with the FOX news network, she said:
"Why would anyone want to give their child an expensive pill…with unacceptable side effects, when he or she could just go into the backyard, pick a few leaves off a plant and make tea…?"

"Cannabinoids are a very viable alternative to treating adolescents with ADD and ADHD…I have a lot of adult patients who swear by it."

In her testimony, before the House Committee on Government Reform on Marijuana (2004) Dr. Jensen discussed the practice of recommending marijuana to patients with ADHD in an 11-page statement. Her testimony summarized hundreds of published scientific articles on the safety/ efficacy of marijuana that have produced strong scientific evidence that marijuana is important medicine.

Her reasons for looking to marijuana as treatment for ADHD?
“The other legal drugs used to treat ADD are helpful in many patients, but they all have side effects….the other five of the nine drugs used to treat ADD in this country haven’t even been scientifically tested…for ADD in children. These are drugs for depression and high blood pressure…Of all the drugs used to treat ADD, cannabis has the least number of serious side effects.

Her explanation for why marijuana is opposed by the pharmaceutical companies:
“The real problem with allowing patients to use Cannabis as a medication is economics…If Cannabis were approved for use in just the ADD/ ADHD market alone, it could significantly impact the $1 Billion a year sales for traditional ADD/ ADHD pharmaceuticals…”

Dr. Tom O'Connell

Dr. Tom O'Connell, a retired surgeon who works with patients in the Bay Area is studying with patients that self-medicate with marijuana. In O’Shaughnessy’s, The Journal of Cannabis in Clinical Practice (Spring 2005) Dr. O'Connell summarized his study of 790 patients:
“…There is universal agreement among applicants who have been diagnosed with and/or treated for ADD that cannabis helps them achieve and retain focus…”

Dr. O’Connell states there is a strong argument for promoting marijuana with ADHD because it is safer than all other medications. In 2004 a statement to Fox news, he said:
“…Although it flies in the face of conventional wisdom, it's nevertheless true that cannabis is far safer and more effective than the prescription agents currently advocated for treatment of ADD-ADHD…”

Is Marijuana Safe?

The preponderance of scientific evidence points to marijuana as being exceptionally safe, for adolescents and adults. Leo Holllister’s two papers Health Aspects of Cannabis (1986) and Health aspects of cannabis: revisited (1998) are widely considered the most authoritative compendia on the safety of marijuana. Hollister’s opinion is best summarized in his 1986 paper:
“…one is forced to conclude that cannabis is relatively safe…toxicity studies of cannabis and its constituents lead to the inescapable conclusion that it is one of the safest drugs ever studied in this way.”

In the many papers that cite Hollister’s work, there is a common theme:
“By any standards, THC must be considered a very safe drug both acutely and on long-term exposure.”

“…although there have been many rumors that the long term use of marijuana leads to irreversible damage to higher brain functions the results of numerous scientific studies have failed to confirm this…Based on the results of the three best studies performed (Schwartz, Pope and Block et al.,) residual cognitive effects are seldom observed and if present are mild in nature.”

FDA Administrative Law Judge Young couldn’t have been clearer in describing the safety of cannabis. He said after a two year FDA rescheduling hearing, that marijuana was one of the safest therapeutic agents known to man. According to ALJ Young marijuana is safer than eating 10 potatoes. His recommendation to reschedule marijuana to schedule II was turned down by President Bushes’ political appointee, FDA Director John Lawn

With the discovery of cannabinoid receptors and a greater understanding of the endocanabinoid system we stand at the dawn of a new era of understanding how the brain works and applying new solutions. This is a time to look at not only creating new agonists and antagonists based on the cannabinoid molecule but also to recognize the medicinal role that cannabis can play not only in treating ADHD but also possibly seizures, Tourette’s Syndrome, PTSD,OCD and panic attacks. We in the US need to reevaluate our attitude regarding phytochemicals.

There is a contemporary movement that physicians practice evidence based medicine. That is much easier said then done. As the recent Vioxx ® example demonstrates FDA approval does not guarantee that serious side effects won’t be discovered after a studied and FDA approved drug is used by tens of millions, rather than a few thousand test subjects. We need to adopt some of the European respect for the value of hundreds and in some cases (as is the case with cannabis) years of human experience with herbal and natural preparations as some sort of evidence. In some instances these traditional remedies, sometimes ridiculed, have fewer side effects and work as well or better than FDA approved , single chemical drugs.

Let’s face it, not all so called research is done by the federal or state government. Most clinical studies are done by drug companies and they are not an unbiased third party. We most rely on the expertise and over site of the FDA to sort the wheat from the chaff. They must pay attention to the science and methodology of the studies submitted. If possible they should have access to the studies which weren’t submitted to them since pharmaceutical companies have been known to provide biased research, rooted in financial conflict and preconceived notions. Costly proprietary drugs are heavily promoted but herbal remedies, which cost the patient relatively little, have at least until recently, been given relatively short shrift by the medical establishment.

Six years ago the CMA, at their annual leadership conference, urged physicians to be aware of their patients’ use of complementary and alternative medicines (CAM). Over 60 % of the average doctors patients use CAM, however at least 40% do not share that fact with their physician. One of those herbs [patients use is cannabis and one of the conditions patients have found it’s useful for is treating ADHD.

Physicians, judges, and researchers are beginning to acknowledge the medical value of cannabis. In the case of treatment for ADHD cannabis and cannabinoids are often an effective, safer alternative then sympathomimetic prescription drugs. These stimulant drugs have an unacceptable side effect profile.

If you want to talk about marijuana, choose a physician that has experience with marijuana. More and more physicians are becoming aware of cannabis medicinal value. UCSD is headquarters for the California Marijuana Research Center. They administer 18 FDA approved smoked cannabis medical clinical studies.

These studies are showing good results and being presented at medical meetings. Bayer is marketing tincture of cannabis in Canada under the trade name Sativex .The International Cannabis Research Society has annual meetings discussing progress being made in how cannabis works for patients in a way which patients say "almost seems like its magic".


At 2:35 PM, Blogger Unknown said...

OMG! I was so glad to come across all your information on marijuana and ADHA. My husband has adha and is diagnosed with bi-polarII and is incarcerated due to,(I believe self medicating) drug use. Trying to calm his ADHD. I'm very concerned about what the Dr. Just perscribed him, Lithium! The side affects are worse than I could have Imagined. And so I thought maybe I could see if there is something I could find in regards to treating ADHD with medicinal marijuana and to my surprise I found this and now I feel much better, but my concern now is until my husband is released from prison (which is five more months) that is five months of the risk of very dangerous side affects. Something needs to change in the USA if marijuana can help sufferers with certain illness's we need to make it possible! Because I came accross this blog I'm going to try and find a Dr. That can help my husband he suffers tremendously from ADHD and if marijuana is an answer I welcome it! Thank you for this informative blog...

At 3:08 AM, Blogger Unknown said...

I know from experience that marijuana works for ADHD. My little brother was diagnosed as a child and went through drug after drug that either didnt work or had horriable side effects, from zombie like fazes to straight out migraines from the medicines they were giving him. He now self medicates with marijuana and for the first time in 10 years he can hold down a job. He's been in the same one now for 4 years and has gotten two big pay raises. His boss knows that he does it and as long as it doenst effect his job then hes ok with it. I just wish they would make it legal already so I dont have to worry about him using it.

At 1:46 PM, Blogger Unknown said...


My wife and I are Thankful that you blogged this information. Our son has been diagnosed with ADHD for 8 yrs now. He is twice exceptional- has a 130 on the Stanford Binet but has ADHD too....poor kid. We have gone through hell with teachers, schools, administrators each year explaining to them our son...his needs...and what works for him being twice exceptional. He is on Concerta- which has been better than all the rest of the meds that have been prescribed to him, but after reading that Concerta has been given a Black Label and has caused child deaths.....I can't do it anymore. He has high blood pressure at 12 yrs of age and he could possibly die from this drug that he is taking to help school teachers with his studies??!! I could never live myself if he had a heart attack and died because of Concerta and I knew about these horrific side effects. I took him off the Concerta and I need a safe alternative. He is going to an International School right now and doing well, but I fear that without---something----the school will not attend to his needs and revoke his attendance at the school. I am a firm advocate for medicinal marijuana use and know a lot of the inside politics behind the pharmaceuticals and the benefits behind marijuana etc. I looked at Sativex as well as a possible solution for our son. Do you or anyone that will read this blog have something that could help our son? Many Thanks!- MR.C

At 4:18 PM, Blogger William said...

I personally have experience with sativa type cannabis strains working wonders on inattentive add. I think Indica is recommended for ADHD and RBS. My one friend with RBS has found recently that getting stoned before studying helps him quite a lot. Seems weird to me, but there's no reason for him to lie to me over it.

At 5:00 PM, Blogger MFrederick said...

I am 51 and had been searching the internet for information on ADHD for my son because he has some tendencies toward having ADHD.. As I was doing my research, I had a Serendipitous discovery and a revelation that I was and still am ADHD. If I only knew this years ago my life would be different now...In Jr High, I would smoke some Marijuana during lunch and then we would have a surprise test after lunch and I got my first ever A+ on a test, It was crazy, under the influence of Marijuana, everything was clear and my focus was clear and singularly directed. It's like I knew everything and even concluded how the teacher designed the test. I never put the two together because I never knew I was ADHD, nor did I have the self confidence to believe, most anything (under the influence)...Then off the cuff, I searched for "Marijuana and ADHD" I read that increased grades was an outcome..I was a D and C-, student...I continued social use and my grades never dropped below a B+, I graduated High School with 98.3 average, even though I tapered off the social use and developed my learning habits. I am still ADHD, I have a family and the use of Marijuana doesn't seem prudent at this point, unless you can take it without the high....It's amazing at the age of 51, I have had this forehead slap with my hand, it is like an awakening and understanding why I was the way I was...I can finally realize...and yes other family members have ADHD also.....that Marijuana was the treatment and didn't even know it, or trust to know it!!!!!

At 6:52 AM, Blogger RaZz0R said...

I was diagnosed with ADD \ ADHD from a very young age. Given a strict diet and sent to many councillors. The ADD mixed with ADHD bought about anger issues as a young person. By the time I was 12 I had already been sent on camps and foster homes as my mother was a single parent & couldn't deal with myself & by sister both being ADD & ADHD. Not long after the age of 12 I had no choice but to move to my fathers or risked being in jail or off the rails. Up until the age of 15 these problems kept on but with no police thank god. Mostly I was prescribed Dextroamphetamine - which is basically speed cut with some other stuff and the side affects were insane including loss of sleep. However at the age of 15 I was given my first cone by a family member. It was noted almost right away that my thinking was more rational, my personality better and more friendly. I am now 31 and have been using it since. However - I am an IT professional and have been since I was 19. I am consistently required to learn new technology and that is where the ADHD & ADD come in to their own. Of course my use of weed is never before or during work, but after. It allows me to sleep correctly, slow the thinking and if the weeds good enough - stop it so I can sleep even better again. I left school before finding it and later tried to finished secondary school but I had already gained real work experience in IT so I never did finish. Later I figured out why I didn't ever do good at school and that is the ADD part where I also have a learning disability. I learn by doing and since a computer gives you direct and instant feed back it responds to the ADHD part. So IT work in the end proved to be great and all the teachers saying to get off the computer really didn't understand what was going on. Plus - 130k a year is awesome pay - all thanks to ADD & ADHD plus being able to tame it with weed when required. Before this - I was on my way to jail. Also for my final bit of this comment - I have many read that weed is a gateway drug. I think not. In my personal experience it is more social impacts that might have a smoker try something else. For me - since I was pretty much given speed in tablet form I have tried the drug to see what would happen, the outcome was the same as the Dextroamphetamine!! Yay. I also experimented with lsd once but it all had nothing to do with smoking. It had to do with my social group at the time and others trying it and it making me wonder what the experience was like. And now at 31 all I do is have my weed, I dont even carry a packet of cigs on me! Also just to shine a little light on ADD + ADHD - I once pegged a doctor about it and got a decent reply. The reason why to this day doctors do not know all about ADD & ADHD is those with have different brain chemicals between the left and right side of the bring (Well for me) and the Dextroamphetamine was meant to even it out. But the affects was like being someone else and watching from outside your body. Give me my weed any day over something made in a lab! :)

At 11:49 AM, Blogger Teleterkji said...

This is good read.
I am diagnosed with adhd,and use cannabis and coffee as daily medicine to maintain a happy brain.
There is however a certain issue that i have to deal with,using this type of apetite-munchies promoting medicine,and that is to avoid sugar laden foods,as they wreck the subtle medicinal effects of cannabis effectively.

At 10:45 AM, Anonymous Anonymous said...

I have a sad story about my childhood with abuses and dealing with my ADHD. I been proven to have ADHD they try to poison me with medication to control it. After I start using marijuana.. I start to think slower and things were improving.. I went back to school. I lived a productive life.. even with tragic childhood and hardship. Now, 20 years later I get pull over for not wearing my seatbelt(I was) and they k9 search me a found marijuana.. Now I am a criminal. Now I am fighting for my life.. I am fighting for my name. It not a crime, its a medicine. I pleaded not guilty. Florida need to change the law. I am risking everything.. my jobs and license.. I been in Florida State hospital most of my childhood years and special schools.. Now, they want be back. I cant let the law ruin my life. Marijuana has help me alot thought the years with so many things. Can I have your support doctor?

At 11:12 PM, Blogger Sam said...

Is Marijuana really helpful in medicines.

At 9:10 PM, Blogger Medhead said...

Nice Post & good research.. Keep spreading the good word of the medicine cannabis. Rosie I would make an edible from cbd rich plant, start with very small bite & work up till you hit the sweet spot..I'm not a Doctor, Just have seen so many people life's improve.

At 10:48 PM, Blogger Mandie said...

Did you ever get to try this route with your sons adhd? I came across this page after wondering if marijuana was ever tested for this.. and it looks promising...

At 10:50 PM, Blogger Mandie said...

Did you ever get to try this route with your sons adhd? I came across this page after wondering if marijuana was ever tested for this.. and it looks promising...

At 10:50 PM, Blogger Mandie said...

Did you ever get to try this route with your sons adhd? I came across this page after wondering if marijuana was ever tested for this.. and it looks promising...

At 5:20 PM, Blogger JamTech said...

Marijuana have a lot of medicinal use

Learn how to use marijuana to treat HIV

At 8:17 AM, Blogger UrbexGirl said...

I am 19 and was diagnosied with ADHD when I was 7 as it can not be diagnosed till that ages in the uk. I took ritilin from 7 until 13 and then took concerta till I was 16. At the age of 16 I then made the decision to come of my medication as I felt that it controlled my mind and I wasnt being the person I was meant to be. Around this time was when I first started smoking weed, I found that it helped calm me down and my mind wasnt rushing with thoughts all the time. I'm now 19 and have been smoking regularly for the last year and a half. I am myself now and lots in my life has changed since I came of my medication. I now have something that I'm about, I have lots more friends then I did at school and feel much more confident about myself. I am all for the use of marajauna to treat ADHD and it angers me that it is not legal in this country. Yes I understand that it's can have side affects but so does every other medication that can be prescribed to you.

At 4:16 PM, Blogger Unknown said...

This comment has been removed by the author.

At 12:50 AM, Blogger Unknown said...


At 11:31 PM, Blogger Unknown said...

This comment has been removed by the author.

At 2:03 PM, Blogger Unknown said...

finally, the right research for the chemical that saved my life!!!

At 3:07 AM, Blogger Unknown said...

Thanks for the post. It is really helpful !
ADHD treatment

At 6:38 PM, Anonymous Anonymous said...

My high schooler has been on 6 different ADHD medications, I was reluctant and refused to let him smoke Marijuana, at the end of his 10th grade he actually brought home a report card with straight A's on top of that teachers made comments of the huge difference in his behavior. said the new medication he was on was really making a difference. I told him see that medication is working. He brought me a full bottle of pills and told me he had been smoking Marijuana. I was in awww. My husband refused to keep letting him smoke it, he dropped out and never finished school. He is now 19, and is back in high school going for his diploma. His father says see, he can do it, he just had to want it bad enough...I hated to tell him sorry buddy, he is smoking marijuana again.

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At 10:31 PM, Blogger lkvkkvkvm.f,f said...

Believe in your children . do reaserch and help. I was the same kid. and still to this day treat my ADHD with marijuana

At 4:31 AM, Blogger Unknown said...

This is a very good post regarding marijuana information by this many people will get to know the correct use of this.How we can use this as a medicine and it is beneficial in improving our health.

At 3:18 PM, Blogger Megan said...

This comment has been removed by the author.

At 3:25 PM, Blogger Megan said...

This comment has been removed by the author.

At 3:29 PM, Blogger Megan said...

This comment has been removed by the author.

At 5:53 PM, Blogger Sal Marley said...

as i read all this, i have flashbacks of my school yrs, I suffered and likely still suffer from ADD, i was given Ritalin for 3 yrs and it wrecked my life, now i have a 11 yr old in AZ going through the same thing. Hopefully this will not do what Ritalin did to me... Thanks Guys!!!!

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At 10:00 AM, Blogger Unknown said...

I suffer from severe ADHD have since I was a young child. The first drug thy put me on was Ritialn. I was on it for many years until I was a sophomore in high school and they switched me to Addorall. Iam still currently taking Addorall. The problem with the amphetamine drugs used to help treat ADHD is the side effects out weigh the good that it does. I experienced loss of appetite, problems sleeping, weight loss, mental dependence they are several more tomany to list really. I've been smoking Marijuana for several years now an it works great. It does the same thing that Amphetamine Drugs do but without the harsh side effects. There are only 3 side effects Marijuana. Happy, Hungry and Sleepy. They have not ever been any fatalities, overdoses in studies involving Medical Marjuina. I think that they should approve Medical Marijuana for ADHD in all states.

At 10:11 AM, Blogger Unknown said...

Very much so. I'm living proof.

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